Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties-Reference-Cited by-同舟云学术

Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties

Published:2017-01-02 Issue:1 Volume:81 Page:59-62
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Chiba Takuya¹,Asami Yukihiro¹²,Suga Takuya¹,Watanabe Yoshihiro¹,Nagai Takayuki¹²,Momose Fumitaka¹²,Nonaka Kenichi¹²,Iwatsuki Masato¹²,Yamada Haruki¹²,Ōmura Satoshi²,Shiomi Kazuro¹²

Affiliation:

1. Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

2. Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan

Abstract

Abstract In the course of screening for new anti-influenza virus antibiotics, we isolated herquline A from a culture broth of the fungus, Penicillium herquei FKI-7215. Herquline A inhibited replication of influenza virus A/PR/8/34 strain in a dose-dependent manner without exhibiting cytotoxicity against several human cell lines. It did not inhibit the viral neuraminidase.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/81/1/59/36838649/bbb0059.pdf

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