Degradation products of mangiferin by gamma irradiation with inhibitory effects on NO production-Reference-Cited by-同舟云学术

Degradation products of mangiferin by gamma irradiation with inhibitory effects on NO production

Published:2016-10-02 Issue:10 Volume:80 Page:2022-2024
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Jo Cheorun¹,Yoon Kyung Young²,Jang Eun Jin²,Kim Tae Hoon³

Affiliation:

1. Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, Korea

2. Department of Food and Nutrition, Yeungnam University, Gyeongsan, Korea

3. Department of Food Science and Biotechnology, Daegu University, Gyeongsan, Korea

Abstract

Abstract The xanthone glucoside mangiferin (1) was converted by γ-irradiation into three new compounds, mangiferdiol (2), mangiferinol (3), and isomangiferinol (4). The new compound 2 containing two hydroxymethyl groups instead of a ketone moiety exhibited significantly improved inhibitory activity against nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 value 47.1 ± 1.7 μM, compared to the mother mangiferin.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/80/10/2022/36832271/bbb2022.pdf

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