Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice-Reference-Cited by-同舟云学术

Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice

Published:2016-06-02 Issue:6 Volume:80 Page:1205-1213
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Sekita Yasuko¹,Murakami Keiji²,Yumoto Hiromichi³,Mizuguchi Hiroyuki⁴,Amoh Takashi²,Ogino Satoshi⁵,Matsuo Takashi³,Miyake Yoichiro²,Fukui Hiroyuki⁶,Kashiwada Yoshiki¹

Affiliation:

1. Department of Pharmacognosy, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

2. Department of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

3. Department of Conservative Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

4. Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

5. Faculty of Medicine, Graduate Schools of Allied Health Sciences, Osaka University, Osaka, Japan

6. Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

Abstract

Abstract Houttuynia cordata (HC) has been commonly used as many traditional remedies in local areas of Japan. Although many pharmacological activities of HC have been reported, the mechanism underlying the effect of HC remains unknown. We conducted the interview survey in Japan to verify how HC was actually used. The interview survey revealed that HC poultice (HCP) prepared from smothering fresh leaves of HC was most frequently used for the treatment of purulent skin diseases including furuncle and carbuncle with high effectiveness. Ethanol extract of HCP (eHCP) showed anti-bacterial effects against methicillin-resistant Staphylococcus aureus (MRSA), and showed an anti-biofilm activity against MRSA. eHCP showed dose-dependent inhibition of S. aureus lipoteichoic acid (LTA)-induced interleukin-8 and CCL20 production in human keratinocyte without any cytotoxicity. These results suggest that HCP is effective for skin abscess and its underlying mechanism might be the complicated multiple activities for both bacteria and host cells.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/80/6/1205/36829932/bbb1205.pdf

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