Chemical constituents of Brazilian Propolis from the state of Bahia and their growth inhibitory activities against cancer cells

Author:

Mitsui Taichi1,Hotta Sho1,Tazawa Shigemi1,Arai Yasuko1,Kato Kenji1,Ichihara Kenji1

Affiliation:

1. Nagaragawa Research Center, Api Co. Ltd., Gifu, Japan

Abstract

Abstract A novel 2-phenoxychromone (1) and five known flavones (2-6) were isolated from northeastern Brazilian propolis in the state of Bahia. The chemical structures of these six compounds were determined by spectroscopic investigations and single-crystal X-ray analysis. The isolated compounds showed growth-inhibitory activities, in varying degrees, against human tumor cell lines. This is the first report on the discovery of a novel 2-phenoxychromone from propolis.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

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