Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence-Reference-Cited by-同舟云学术

Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence

Published:2018-05-04 Issue:5 Volume:82 Page:900-903
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Inoue Hirofumi¹,Hanawa Nobuaki²,Katsumata-Tsuboi Rie¹,Katsumata Shi-Ichi²,Takahashi Nobuyuki¹,Uehara Mariko¹

Affiliation:

1. Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety, Tokyo University of Agriculture, Tokyo, Japan

2. Faculty of Applied Bioscience, Department of Food and Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan

Abstract

Abstract To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray. Furthermore, DFO treatment increased senescence marker β-galactosidase activity, whereas this activity was attenuated by overexpression of SMP30. Our data suggested that down-regulation of SMP30 drives cell senescence in iron-chelated condition.

Funder

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/82/5/900/36831010/bbb0900.pdf

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