Inhibition of melanin production and promotion of collagen production by the extract of Kuji amber

Author:

Suzuki Satoshi1,Abe Junpei2,Kudo Yui3,Shirai Masayuki4,Kimura Ken-ichi23

Affiliation:

1. General Headquarters, Misho Corporation Limited, Tokyo, Japan

2. Chemical Biology Laboratory, Graduate School of Arts and Sciences, Iwate University, Morioka, Japan

3. Department of Biological Chemistry and Food Science, Faculty of Agriculture, Iwate University, Morioka, Japan

4. Department of Chemistry and Bioengineering, Faculty of Science and Engineering, Iwate University, Morioka, Japan

Abstract

ABSTRACT Kuji amber is fossilized tree resin of the Late Cretaceous in Japan. In this study, new biological activities of ethanol extract of Kuji amber (EtOH ext.) and supercritical carbon dioxide fluid extract of Kuji amber (scCO2 ext.) were examined. Both EtOH ext. and scCO2 ext. inhibited melanin production in B16 mouse melanoma cells and promoted collagen production in human skin fibroblast SF-TY cells. The scCO2 ext. had more potent activity than that of EtOH ext. and may depend on the efficiency of the extraction. The main new biologically active compound in Kuji amber, kujigamberol had no activities against melanin production, however, it promoted collagen production at low concentrations. A biologically active compound having a different structure, spirolactone norditerpenoid, showed both the inhibition activity against melanin production and the promotion activity of collagen production in a dose dependent manner. EtOH ext. and scCO2 ext., which include both kujigamberol and spirolactone norditerpenoid, have not only anti-allergy activity, but also inhibit melanin production and promote collagen production.

Funder

New Energy and Industrial Technology Development Organization

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

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