Affiliation:
1. Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
Abstract
ABSTRACT
Oxytocin, has various physiological functions that have been well studied and many that remain unknown. Here, we aimed to determine new physiological functions of oxytocin using Caenorhabditis elegans. Oxytocin treatment promoted the restoration of movement after heat stress and enhanced the viability under heat stress. However, oxytocin had no effect on the life span and only little effect on the oxidative stress tolerance. In contrast, oxytocin treatment didn’t promote the restoration of movement or enhance the viability of deficient mutants of ntr-1/2, which is the gene encoding the oxytocin receptor. In addition, for mutants of daf-16, daf-2, tax-4, and some insulin-like peptides, the heat stress tolerance effect by oxytocin was canceled. Furthermore, oxytocin increased the expression levels of the DAF-16 target genes. Our results suggest that oxytocin treatment promoted the heat stress tolerance of C. elegans via the insulin/IGF-1 signaling pathway.
Publisher
Oxford University Press (OUP)
Subject
Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology
Reference36 articles.
1. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin;Tuppy;Biochim Biophys Acta,1953
2. The synthesis of oxytocin;Vigneaud;J Am Chem Soc,1953
3. Synthesis, transport and release of posterior pituitary hormones;Brownstein;Science,1980
4. On some physiological actions of ergot;Dale;J Physiol,1906
5. Oxytocin is required for nursing but is not essential for parturition or reproductive behavior;Nishimori;PNAS,1996
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献