The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase

Author:

Nitta Yoko1,Ito Hideyuki1,Komori Hirohumi2,Ueno Hiroshi3,Takeshima Daiki1,Ito Mikiko4,Sakaue Motoyoshi4,Kikuzaki Hiroe5

Affiliation:

1. Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja-shi, Okayama, Japan

2. Faculty of Education, Kagawa University, Takamatsu, Kagawa, Japan

3. Laboratory of Applied Microbiology & Biochemistry, Ryukoku University, Ohtsu, Shiga, Japan

4. Graduate School of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan

5. Department of Food Science and Nutrition, Nara Women‘s University, Kitauoyanishi-machi, Nara, Japan

Abstract

ABSTRACT Rugosin G, an ellagitannin trimer, was isolated from the water-soluble fraction of red rose petals, and its inhibitory activity against recombinant human histidine decarboxylase was investigated. Rugosin G showed potent inhibition compared to ellagitannin monomers and a dimer with macrocyclic structure (oenothein B), suggesting the potent inhibition of rugosin G was attributed to its linear oligomeric conformation. Abbreviations: HDC, histidine decarboxylase; Me2CO, acetone; EtOAc, ethyl acetate

Funder

Japan Society for the Promotion of Science Grants-in Aid for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

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