Choline and betaine ameliorate liver lipid accumulation induced by vitamin B6 deficiency in rats-Reference-Cited by-同舟云学术

Choline and betaine ameliorate liver lipid accumulation induced by vitamin B6 deficiency in rats

Published:2017-02-01 Issue:2 Volume:81 Page:316-322
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kitagawa Erina¹²,Yamamoto Tatsuya³,Fujishita Mayuko³,Ota Yuki³,Yamamoto Kohei¹,Nakagawa Tomoyuki¹³⁴,Hayakawa Takashi¹³⁴

Affiliation:

1. The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan

2. Faculty of Health and Human Life, Nagoya Bunri University, Inazawa, Japan

3. The Graduate School of Applied Biological Sciences, Gifu University, Gifu, Japan

4. Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan

Abstract

Abstract We investigated the efficacy of supplementing the diet with choline or betaine in ameliorating lipid accumulation induced by vitamin B6 (B6) deficiency in rat liver. Male Wistar rats were fed a control, B6-deficient, choline-supplemented (2, 4, or 6 g choline bitartrate/kg diet) B6-deficient diet or betaine-supplemented (1, 2, or 4 g betaine anhydrous/kg diet) B6-deficient diet for 35 d; all diets contained 9 g l-methionine (Met)/kg diet. Choline or betaine supplementation attenuated liver lipid deposition and restored plasma lipid profiles to control levels. These treatments restored the disruptions in Met metabolism and the phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio induced by B6 deficiency in liver microsomes. These results suggest that choline and betaine ameliorated liver lipid accumulation induced by B6 deficiency via recovery of Met metabolism and very low-density lipoprotein secretion by restoring the supply of PC derived from PE.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/81/2/316/36844324/bbb0316.pdf

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