A new sarasinoside congener, sarasinoside M2, from a marine sponge collected in the Solomon Islands

Author:

Puilingi Clyde Gorapava1,Kudo Yuta1,Cho Yuko1,Konoki Keiichi1,Yotsu-Yamashita Mari1

Affiliation:

1. Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Abstract

Abstract A new sarasinoside congener (sarasinoside M2) and known sarasinoside B1 were obtained from a marine sponge. Sarasinoside M2 was suggested to have the same aglycon as sarasinoside M although the internal glucose in its sugar moiety is replaced by xylose. Sarasinosides B1 and M2 showed moderate cytotoxicity (approximate IC50 5–18 μM) toward Neuro-2a and HepG2 cell lines.

Funder

JSPS

Japanese Government (Monbukagakusho: MEXT) Scholarship

KAKENHI

Funding Program for the Next Generation World-Leading Researchers from JSPS

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

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