Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts-Reference-Cited by-同舟云学术

Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts

Published:2017-02-01 Issue:2 Volume:81 Page:376-379
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Uehara Eriko¹,Hokazono Hideki¹,Sasaki Takako²,Yoshioka Hidekatsu²,Matsuo Noritaka²

Affiliation:

1. Sanwa Shurui Co. Ltd., Usa, Japan

2. Faculty of Medicine, Department of Matrix Medicine, Oita University, Yufu, Japan

Abstract

Abstract We examined the effects of GABA on type I collagen gene expression in normal human dermal fibroblasts. Real-time PCR analysis indicated GABA increased the level of type I collagen transcripts, and suppressed the expression of matrix metalloproteinase-1, which is a collagen-degrading enzyme. These results suggest GABA improves the skin elasticity by regulating type I collagen expression.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/81/2/376/36844194/bbb0376.pdf

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