Effect of sorghum ethyl-acetate extract on benign prostatic hyperplasia induced by testosterone in Sprague–Dawley rats

Author:

Ryu Jae-Myun1,Jang Gwi Yeong2,Park Dongsun3,Woo Koan Sik4,Kim Tae Myoung1,Jeong Heon Sang5,Kim Dae Joong1

Affiliation:

1. Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea

2. Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Korea

3. Department of Biology Education, Korea National University of Education, Cheongju, Korea

4. Department of Central Area Science, National Institute of Crop Science, Rural Development Administration, Suwon, Korea

5. Department of Food Science and Biotechnology, Chungbuk National University, Cheongju, Korea

Abstract

ABSTRACT Benign prostatic hyperplasia (BPH) is commonly observed in men > 50 years worldwide. Phytotherapy is one of the many treatment options. Sorghum (Sorghum bicolor L.) contains various health-improving phytochemicals with antioxidant and inhibitory activities on cell proliferation, both in vitro and in vivo. To confirm the effects of Donganme sorghum ethyl-acetate extract (DSEE) on BPH, we induced BPH in Spragye–Dawley rats using exogenous testosterone. We measured prostate weight, examined prostrates histopathologically, and analyzed mRNAs associated with male hormones and proteins associated with cell proliferation in the prostate. DSEE inhibited weight gain of the prostate; decreased mRNA expressions of androgen receptor and 5α-reductase II; and improved histopathological symptoms, the protein-expressed ratio of Bax/Bcl-2, and the oxidative status of BPH induced by testosterone in SD rats. Therefore, DSEE may have potential as a preventive or therapeutic agent against BPH.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

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