Influence of AHRR Pro189Ala polymorphism on kidney functions-Reference-Cited by-同舟云学术

Influence of AHRR Pro189Ala polymorphism on kidney functions

Published:2017-06-03 Issue:6 Volume:81 Page:1120-1124
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Nakayama Kazuhiro¹,Saito Shinichi²³,Watanabe Kazuhisa¹,Miyashita Hiroshi⁴,Nishijima Fuyuhiko⁵,Kamo Yoshie³,Tada Koji³,Ishizuka Satoshi³,Niwa Toshimitsu²⁶,Iwamoto Sadahiko¹,Shimizu Hidehisa²³⁷

Affiliation:

1. Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

2. Department of Advanced Medicine for Uremia, Nagoya University Graduate School of Medicine, Aichi, Japan

3. Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Hokkaido, Japan

4. Health Care Center, Jichi Medical University, Tochigi, Japan

5. Biomedical Research Laboratories, Kureha Co., Tokyo, Japan

6. Faculty of Health and Nutrition, Shubun University, Aichi, Japan

7. Faculty of Life and Environmental Science, Department of Life Science and Biotechnology, Shimane University, Shimane, Japan

Abstract

Abstract The function of aryl hydrocarbon receptor repressor (AHRR) in the kidney is unclear. The present study investigated associations between AHRR Pro189Ala polymorphism and estimated glomerular filtration rates (eGFR), serum creatinine, and hemoglobin levels in 2775 Japanese adults without diabetes. In addition, we examined whether AHRR expression levels in the kidney of control and chronic kidney disease (CKD) rats were changed. Multiple linear regression analyses showed that carriers of the Ala allele had increased eGFR and lower concentrations of serum creatinine and hemoglobin (p < 0.05). Immunohistochemical analysis showed that the expression of AHRR was upregulated in the kidneys of rats with CKD. These findings suggest that AHRR plays distinct roles in kidney functions and hemoglobin values. The effects of the AHRR polymorphism might be intensified in the kidneys of patients with CKD.

Funder

Grants-in-Aid for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/81/6/1120/36845858/bbb1120.pdf

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