New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793-Reference-Cited by-同舟云学术

New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793

Published:2020-08-02 Issue:8 Volume:84 Page:1570-1575
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kawahara Teppei¹,Itoh Masashi²,Izumikawa Miho¹,Kagaya Noritaka³,Sakata Noriaki²,Tsuchida Toshio²,Shin-ya Kazuo³⁴⁵

Affiliation:

1. Japan Biological Informatics Consortium (JBIC), Tokyo, Japan

2. Research & Development Division, MicroBiopharm Japan Co., Ltd (MBJ), Iwata, Japan

3. National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan

4. The Biotechnology Research Center, The University of Tokyo, Tokyo, Japan

5. Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo, Japan

Abstract

Abstract Chemical screening of culture medium from the soil fungus Stachybotrys sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (1), MBJ-0031 (2) and MBJ-0032 (3). Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 1–3 were determined by modified Mosher’s and Marfey’s methods. In addition, cytotoxic and antimicrobial evaluations of the compounds were conducted.

Funder

Japan Society for the Promotion of Science

Ministry of Economy, Trade and Industry

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/84/8/1570/36827320/bbb1570.pdf

Reference19 articles.

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2. New hydroxamate metabolite, MBJ-0003, from Micromonospora sp. 29867;Kawahara;J Antibiot,2013

3. Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria sp. f26111;Kawahara;J Antibiot,2013

4. Three eremophilane derivatives, MBJ-0011, MBJ-0012 and MBJ-0013, from an endophytic fungus Apiognomonia sp. f24023;Kawahara;J Antibiot,2013

5. New chaetoglobosin derivatives, MBJ-0038, MBJ-0039 and MBJ-0040, isolated from the fungus Chaetomium sp. f24230;Kawahara;J Antibiot,2013

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