Identification of crypto- and neochlorogenic lactones as potent xanthine oxidase inhibitors in roasted coffee beans-Reference-Cited by-同舟云学术

Identification of crypto- and neochlorogenic lactones as potent xanthine oxidase inhibitors in roasted coffee beans

Published:2014-12-02 Issue:12 Volume:78 Page:2110-2116
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Honda Sari¹,Miura Yukari¹,Masuda Akiko²,Masuda Toshiya¹

Affiliation:

1. Graduate School of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan

2. Faculty of Human Life Science, Shikoku University, Tokushima, Japan

Abstract

Abstract Xanthine oxidase (XO) inhibitory activity has been found in boiling water extracts from roasted coffee beans. Therefore, assay-guided purification of the extracts was performed using size-exclusion column chromatography, and subsequently with reversed phase HPLC to afford lactone derivatives of chlorogenic acids. Among the tested lactones, crypto- and neochlorogenic lactones showed potent XO inhibitory activities compared with three major chlorogenic acids found in coffee beans. These XO inhibitory lactones may ameliorate gout and hyperuricemia in humans who drink coffee.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/78/12/2110/36820905/bbb2110.pdf

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