Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders

Author:

Matveeva Anna12,Watters Orla23,Rukhadze Ani4,Khemka Niraj12,Gentile Debora4,Perez Ivan Fernandez12,Llorente-Folch Irene12,Farrell Cliona12,Lo Cacciato Elide4,Jackson Joshua4,Piazzesi Antonia4,Wischhof Lena4,Woods Ina12,Halang Luise12,Hogg Marion235,Muñoz Amaya Garcia6,Dillon Eugène T.7,Matallanas David6,Arijs Ingrid89,Lambrechts Diether89,Bano Daniele4,Connolly Niamh M. C.12,Prehn Jochen H. M.123ORCID

Affiliation:

1. Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland

2. Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland

3. SFI FutureNeuro Research Centre, Dublin 2, Ireland

4. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

5. Department of Biosciences, Nottingham Trent University, Clifton Campus, Nottingham, UK

6. Systems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, Belfield, Ireland

7. Mass Spectrometry Resource, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin 4, Ireland

8. Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and

9. VIB Center for Cancer Biology, Leuven, Belgium

Publisher

Informa UK Limited

Subject

Neurology (clinical),Neurology

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