1. Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy
2. Center of Epidemiology, Biostatistics and Medical Information Technology, Polytechnic University of Marche, Ancona, Italy
3. Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy, and
4. Regional Health Agency of Marche, Ancona, Italy