Affiliation:
1. Department of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Japan
2. Department of Orthopaedics, Kyoto Okamoto Memorial Hospital, Kyoto, Japan
3. Institute of Ageing and Chronic Disease, Musculoskeletal Biology II, University of Liverpool, Liverpool, UK
Abstract
Abstract
Objectives
Elderly-onset rheumatoid arthritis (EORA) is reported to differ from young-onset rheumatoid arthritis (YORA) with regard to patient background and drug treatment. We examined the amount of drug administered to patients who achieved low disease activity (LDA) for rheumatoid arthritis at our hospital.
Methods
Demographics, clinical history, and treatments were compared between patients with EORA (n = 70) and YORA (n = 190).
Results
There was a significant difference in the average age (73.8 vs. 57.8 years), disease duration (6.66 vs. 14.7 years), and sex (62.9% males vs. 83.7% females), but no difference in rheumatoid factor positivity (85.3% vs. 80.7%), anti-citrullinated peptide antibody positivity (86.5% vs. 87.7%), simplified disease activity index (4.28 vs. 4.59), or disease activity score 28-CRP (1.99 vs. 2.04) in the EORA and YORA groups, respectively. There were also no significant differences in prednisolone use (37.1% vs. 36.3%), amount of methotrexate administered (MTX) (1.45 vs. 1.41 mg), and MTX use (55.7% vs. 65.3%). However, the MTX dose (2.89 vs. 4.09 mg/week, p = .011) and overall biologics use (32.9% vs. 56.3%, p = .0012) were significantly lower in patients with EORA than in those with YORA.
Conclusion
Patients with EORA may be able to achieve LDA with lower drug dosage than those with YORA.
Publisher
Oxford University Press (OUP)
Cited by
3 articles.
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