Phase 2 study of parsaclisib (INCB050465), a highly selective, next-generation PI3Kδ inhibitor, in relapsed or refractory diffuse large B-cell lymphoma (CITADEL-202)

Author:

Coleman Morton1,Belada David2,Casasnovas René-Olivier3,Gressin Rémy45,Lee Hui-Peng6,Mehta Amitkumar7ORCID,Munoz Javier8,Verhoef Gregor9,Corrado Claudia10,DeMarini Douglas J.10,Zhao Wanying10,Li Jia10,Fay Keith11

Affiliation:

1. Clinical Research Alliance/Weill Cornell Medicine, New York, NY, USA

2. 4th Department of Internal Medicine – Haematology, Charles University, Hospital and Faculty of Medicine, Hradec Králové, Czech Republic

3. University Hospital F. Mitterrand and Inserm UMR 1231, Dijon, France

4. Department of Oncohaematology, University Hospital Grenoble-Alpes, Grenoble, France

5. Institute for Advanced Biosciences, Inserm U 823, Grenoble, France

6. Flinders Medical Centre, Bedford Park, SA, Australia

7. UAB School of Medicine, Birmingham, AL, USA

8. Banner MD Anderson Cancer Center, Gilbert, AZ, USA

9. Department of Hematology, University Hospitals Leuven, Leuven, Belgium

10. Incyte Corporation, Wilmington, DE, USA

11. Department of Haematology, St Vincent’s Hospital, Darlinghurst, NSW, Australia

Funder

Incyte Corporation

Publisher

Informa UK Limited

Subject

Cancer Research,Oncology,Hematology

Reference24 articles.

1. Diffuse large B-cell lymphoma

2. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

3. NCCN Guidelines® B-Cell Lymphomas Version 1.2020. U.S. Plymouth Meeting (PA): National Comprehensive Cancer Network; 2020. https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf

4. Diffuse large B-cell lymphoma: R-CHOP failure—what to do?

5. The rationale for combination therapy in patients with aggressive B-cell non-Hodgkin lymphoma: ten questions

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