Data derived extrapolation factors (DDEFs) for rat to human interspecies extrapolation for the HPPD inhibitor mesotrione
Author:
Affiliation:
1. Product Safety, Syngenta Crop Protection LLC, Greensboro, NC, USA
2. Syngenta Jealott’s Hill International Research Centre, Bracknell, UK
3. Syngenta Canada Inc, Guelph, Canada
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.1080/10408444.2024.2353174
Reference43 articles.
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2. Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance
3. Species differences and human relevance of the toxicity of 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors and a new approach method in vitro for investigation
4. Keratopathy in tyrosinemia;Burns RP;Birth Defects Orig Artic Ser,1976
5. Lack of Total Independence of Uncertainty Factors (UFs): Implications for the Size of the Total Uncertainty Factor
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