Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation

Author:

Boobis Alan1,Brown Paul2,Cronin Mark Timothy David3,Edwards James4,Galli Corrado Lodovico5,Goodman Jay6,Jacobs Abigail2,Kirkland David7,Luijten Mirjam8,Marsaux Cyril9,Martin Matthew10,Yang Chihae111213,Hollnagel Heli Miriam14

Affiliation:

1. Department of Medicine, Imperial College London, London, UK;

2. US Food and Drug Administration, Silver Spring, MD, USA;

3. School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK;

4. DSM Nutritional Products Ltd, Kaiseraugst, Switzerland;

5. Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy;

6. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA;

7. Kirkland Consulting, Tadcaster, UK;

8. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands;

9. ILSI Europe a.i.s.b.l., Brussels, Belgium;

10. Environmental Protection Agency, Washington, DC, USA;

11. Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA;

12. Molecular Networks GmbH, Nürnberg, Germany;

13. Altamira LLC, Columbus, OH, USA;

14. Dow Europe GmbH, Horgen, Switzerland

Publisher

Informa UK Limited

Subject

Toxicology

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