From cultivation to cancer: formation of N -nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications

Author:

Stanfill Stephen B.1,Hecht Stephen S.2,Joerger Andreas C.3,González Pablo J.4,Maia Luisa B.5,Rivas Maria G.4,Moura José J. G.5,Gupta Alpana K.6,Le Brun Nick E.7,Crack Jason C.7,Hainaut Pierre8,Sparacino-Watkins Courtney9,Tyx Robert E.1,Pillai Suresh D.10,Zaatari Ghazi S.11,Henley S. Jane12,Blount Benjamin C.1,Watson Clifford H.1,Kaina Bernd13,Mehrotra Ravi14

Affiliation:

1. Tobacco and Volatiles Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA

2. Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3. Structural Genomics Consortium (SGC), Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany

4. Department of Physics, Universidad Nacional Litoral, and CONICET, Santa Fe, Argentina

5. Department of Chemistry, LAQV, REQUIMTE, NOVA School of Science and Technology (FCT NOVA), Caparica, Portugal

6. Independent Research Consultant (Cancer), Noida, India

7. School of Chemistry, Centre for Molecular and Structural Biochemistry, University of East Anglia, Norwich, UK

8. Institute for Advanced Biosciences, Grenoble Alpes University, Grenoble, France

9. University of Pittsburgh, School of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, Vascular Medicine Institute, PA, USA

10. Department of Food Science & Technology, National Center for Electron Beam Research, Texas A&M University, College Station, TX, USA

11. Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon

12. Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA

13. Institute of Toxicology, University Medical Center, Mainz, Germany

14. Centre for Health, Innovation and Policy Foundation, Noida, India

Funder

Deutsche Forschungsgemeinschaft

Fundação para a Ciência e a Tecnologia, MCTES

PT National Funds

German Research Foundation

Structural Genomics Consortium

Bayer AG

Boehringer Ingelheim

Bristol Myers Squibb

Genentech

Genome Canada

Ontario Genomics Institute

EU/EFPIA/OICR/McGill/KTH/Diamond Innovative Medicines Initiative 2 Joint Undertaking

Janssen

Merck KGaA

Pfizer

Takeda

UK’s Biotechnology and Biological Sciences Research Council

US Centers for Disease Control and Prevention

American Lung Association

National Center for Chronic Disease Prevention and Health Promotion

Department of Science and Technology, Ministry of Science and Technology

Universidade do Algarve Faculdade de Ciências e Tecnologia

Publisher

Informa UK Limited

Subject

Toxicology

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