Investigations on learning and memory function in extended one-generation reproductive toxicity studies – when considered needed and based on what?

Author:

Arts Josje H. E.1,Faulhammer Frank2,Schneider Steffen3,Salverda Joanne G. W.1

Affiliation:

1. Nouryon Functional Chemicals B.V., Deventer, The Netherlands

2. GB Product Stewardship – Regulations, Toxicology and Ecology, BASF SE, Ludwigshafen, Germany

3. Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany

Publisher

Informa UK Limited

Subject

Toxicology

Reference34 articles.

1. Effects of Mild Perinatal Hypothyroidism on Cognitive Function of Adult Male Offspring

2. AOP-Wiki. 2023a. Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment; [accessed 2023 Mar 31]. https://aopwiki.org/aops/54.

3. AOP-Wiki. 2023b. T4 in serum, decreased leads to T4 in neuronal tissue, decreased; [accessed 2023 Mar 31]. https://aopwiki.org/relationships/312.

4. Is there a rationale for direct dosing of chemicals to nursing pups in the EOGRTS (OECD 443)?

5. Developmental neurotoxicity of Propylthiouracil (PTU) in rats: Relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes

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