The Tg.AC (v-Ha-ras) Transgenic Mouse: Nature of the Model-Reference-Cited by-同舟云学术

The Tg.AC (v-Ha-ras) Transgenic Mouse: Nature of the Model

Published:2001-01 Issue:1_suppl Volume:29 Page:51-59
ISSN:0192-6233
Container-title:Toxicologic Pathology
language:en
Short-container-title:Toxicol Pathol

Author:

Tennant Raymond W.¹,Stasiewicz Stanley²,Eastin William C.³,Mennear John H.⁴,Spalding Judson W.²

Affiliation:

1. National Institute of Environmental Health Sciences, Laboratory of Environmental Carcinogenesis and Mutagenesis, Research Triangle Park, North Carolina 27709, tennant@niehs.nih.gov

2. National Institute of Environmental Health Sciences, Laboratory of Environmental Carcinogenesis and Mutagenesis, Research Triangle Park, North Carolina 27709

3. National Institute of Environmental Health Sciences, Environmental Toxicology Program, Research Triangle Park, North Carolina 27709

4. 103 Eagle Court, P.O. Box 5032, Cary, North Carolina 27511

Abstract

The Tg.AC (v-Ha-ras) transgenic mouse model provides a reporter phenotype of skin papillomas in response to either genotoxic or nongenotoxic carcinogens. In common with the conventional bioassay, the Tg.AC model responds to known human carcinogens and does not respond to noncarcinogens. It also does not respond to most chemicals that are positive in conventional bioassays principally at sites of high spontaneous tumor incidence. The mechanism of response of the Tg.AC model is related to the structure and genomic position of the transgene and the induction of transgene expression through specific mediated interactions between the chemicals and target cells in the skin.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1080/019262301753178474

Reference32 articles.

1. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

2. Dermal Carcinogenicity in Transgenic Mice: Relative Responsiveness of Male and Female Hemizygous and Homozygous Tg.AC Mice to 12-O-Tetradecanoylphorbol 13-Acetate (TPA) and Benzene

3. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

4. Kinetics of wound-induced v-Ha-ras transgene expression and papilloma development in transgenic Tg.AC mice

5. Oral administration of dimethylvinyl chloride increases frequency of forestomach papillomas in Tg.AC mice

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