Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions

Author:

Van Lancker Kelly12ORCID,Tarima Sergey3ORCID,Bartlett Jonathan4ORCID,Bauer Madeline5,Bharani-Dharan Bharani6,Bretz Frank78ORCID,Flournoy Nancy9ORCID,Michiels Hege2ORCID,Olarte Parra Camila4ORCID,Rosenberger James L.10ORCID,Cro Suzie11ORCID

Affiliation:

1. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

2. Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium

3. Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI

4. Department of Mathematical Sciences, University of Bath, Bath, UK

5. Division of Infectious Diseases, Keck School of Medicine, University of Southern California (ret), Los Angeles, CA

6. Novartis Pharmaceuticals, East Hanover, NJ

7. Novartis Pharma AG, Basel, Switzerland

8. Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria

9. Department of Statistics, University of Missouri (emerita), Columbia, MO

10. National Institute of Statistical Sciences, and Department of Statistics, Penn State University, University Park, PA

11. Imperial Clinical Trials Unit, Imperial College London, London, UK

Funder

Fulbright Belgium

Belgian American Educational Foundation

VLAIO

Department of Health and Human Services of the National Institutes of Health

UK Medical Research Council

NIHR advanced research fellowship (NIHR

National Institutes of Health

NIHR or the Department of Health and Social Care

Agentschap Innoveren en Ondernemen

Medical Research Council (MRC) International Centre for Genomic Medicine in Neuromuscular Disease

National Institute of Health Research

Publisher

Informa UK Limited

Subject

Pharmaceutical Science,Statistics and Probability

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