Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis

Author:

Keshawarz Amena1ORCID,Joehanes Roby12,Ma Jiantao13,Lee Gha Young12,Costeira Ricardo4,Tsai Pei-Chien456ORCID,Masachs Olatz M.4,Bell Jordana T.4,Wilson Rory7,Thorand Barbara89,Winkelmann Juliane10111213,Peters Annette891415,Linseisen Jakob16,Waldenberger Melanie715,Lehtimäki Terho171819,Mishra Pashupati P.171819,Kähönen Mika1820,Raitakari Olli212223,Helminen Mika2425,Wang Carol A.2627,Melton Phillip E.2829,Huang Rae-Chi30,Pennell Craig E.2527,O’Sullivan Therese A.31,Ochoa-Rosales Carolina3233,Voortman Trudy32,van Meurs Joyce B.J.34,Young Kristin L.35,Graff Misa35,Wang Yujie35,Kiel Douglas P.3637,Smith Caren E.38,Jacques Paul F.338,Levy Daniel12ORCID

Affiliation:

1. Framingham Heart Study, Framingham, Framingham, MA, USA

2. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

3. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA

4. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK

5. Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan

6. Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan

7. Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg, Germany

8. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany

9. German Center for Diabetes Research (DZD), München-Neuherberg, Germany

10. Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany

11. Institute of Human Genetics, School of Medicine, Technical University of Munich, Munich, Germany

12. Chair of Neurogenetics, School of Medicine, Technical University of Munich, Munich, Germany

13. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

14. Chair of Epidemiology, Medical Faculty, Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany

15. German Center for Cardiovascular Research (DZHK), München Heart Alliance, Munich, Germany

16. Chair of Epidemiology, University Augsburg at University Hospital Augsburg, Augsburg, Germany

17. Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

18. Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

19. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland

20. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

21. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

22. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

23. Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland

24. Tays Research Services, Tampere University Hospital, Tampere, Finland

25. Faculty of Social Sciences, Health Sciences, Tampere University, Tampere, Finland

26. School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia

27. Hunter Medical Research Institute, Newcastle, New South Wales, Australia

28. Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia

29. School of Population and Global Health, University of Western Australia, Perth, Australia

30. Nutrition & Health Innovation Research Institute, Edith Cowan University, Perth, Australia

31. School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia

32. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

33. Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile

34. Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands

35. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Hebrew Senior Life, Chapel Hill, North Carolina, USA

36. Department of Medicine, Beth Israel Deaconess Medical Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA

37. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

38. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

Funder

the National Institutes of Health

National Heart, Lung, and Blood Institute

National Institutes of Health

Ministry of Education

Biotechnology and Biological Sciences Research Council

JPI HDHL DIMENSION project

Wellcome Trust

Medical Research Council

Horizon 2020

National Institute for Health Research

King’s College London

Academy of Finland

Social Insurance Institution of Finland

Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals

Juho Vainio Foundation

Finnish Foundation for Cardiovascular Research

Finnish Cultural Foundation

Sigrid Jusélius Foundation

Tampere Tuberculosis Foundation

European Research Council

Canadian Institutes of Health Research

University of Western Australia

Women and Infants Research Foundation

Edith Cowan University

Murdoch University

University of Notre Dame Australia

Raine Medical Research Foundation

Erasmus University Rotterdam

The Netherlands Organisation for Scientific Research

The Netherlands Organisation for Health Research and Development

Research Institute for Diseases in the Elderly

The Netherlands Genomics Initiative

Ministry of Health

European Commission

National Human Genome Research Institute

National Center for Research Resources

Publisher

Informa UK Limited

Subject

Cancer Research,Molecular Biology

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