Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO

Author:

Song Ashley Y.12,Bulka Catherine M.3,Niemiec Sierra S.4,Kechris Katerina4,Boyle Kristen E.5,Marsit Carmen J.6,O’Shea T. Michael7,Fry Rebecca C.8,Lyall Kristen9,Fallin M. Daniele10,Volk Heather E.1,Ladd-Acosta Christine1211ORCID

Affiliation:

1. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

2. Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

3. College of Public Health, University of South Florida, Tampa, FL, USA

4. Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

5. Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

6. Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

7. Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA

8. Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

9. A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA

10. Rollins School of Public Health, Emory University, Atlanta, GA, US

11. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Funder

National Institutes of Health

Publisher

Informa UK Limited

Subject

Cancer Research,Molecular Biology

Reference24 articles.

1. Bureau TUSC. Child and Adolescent Health Measurement Initiative. 2018-2019 National Survey of Children’s Health (NSCH) data query. Data Resource Center for Child and Adolescent Health supported by the U.S. Department of Health and Human Services Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau (MCHB). 2020. [cited 2023 May 9]. www.childhealthdata.org

2. Addressing Early Childhood Emotional and Behavioral Problems

3. An epigenetic biomarker of aging for lifespan and healthspan

4. DNA methylation GrimAge strongly predicts lifespan and healthspan

5. Prediction of gestational age based on genome-wide differentially methylated regions

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