Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

Author:

Laplana Marina1ORCID,Bieg Matthias23ORCID,Faltus Christian14,Melnik Svitlana1,Bogatyrova Olga1,Gu Zuguang35,Muley Thomas67,Meister Michael67,Dienemann Hendrik78,Herpel Esther9,Amos Christopher I.10,Schlesner Matthias511ORCID,Eils Roland2312,Plass Christoph1,Risch Angela14713ORCID

Affiliation:

1. Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

2. Center for Digital Health, Berlin Institute of Health and Charité – Universitätsmedizin Berlin, Berlin, Germany

3. Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany

4. Department of Biosciences, Allergy-Cancer-BioNano Research Centre, University of Salzburg, Salzburg, Austria

5. Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

6. Translational Research Unit, Thoraxklinik-Heidelberg gGmbH, University of Heidelberg, Heidelberg, Germany

7. Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany

8. Department of Thoracic Surgery, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany

9. Tissue Bank of the National Center for Tumor Diseases (NCT) and Institute of Pathology, Heidelberg University Hospital, Germany

10. Department of Medicine, Baylor College of Medicine, Houston, TX, United States

11. Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany

12. Health Data Science Unit, University Hospital Heidelberg, Heidelberg, Germany

13. Cancer Cluster Salzburg, Austria

Funder

Deutsche Krebshilfe

National Institutes of Health

Deutsches Zentrum für Lungenforschung

Publisher

Informa UK Limited

Subject

Cancer Research,Molecular Biology

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