Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells

Author:

Schamschula Esther1ORCID,Lahnsteiner Angelika1,Assenov Yassen2ORCID,Hagmann Wolfgang2,Zaborsky Nadja34,Wiederstein Markus1,Strobl Anna1,Stanke Frauke56,Muley Thomas78,Plass Christoph28,Tümmler Burkhard56,Risch Angela1248ORCID

Affiliation:

1. Department of Biosciences, University of Salzburg, Salzburg, Austria

2. Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

3. Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Salzburg, Austria

4. Cancer Cluster Salzburg, Salzburg, Austria

5. Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and NeonatologyClinic for Pediatric Pneumology, Allergology and Neonatology, Hannover, Germany

6. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany

7. Translational Research Unit, Thoraxklinik Heidelberg, University of Heidelberg, Germany

8. Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany

Funder

German Federal Ministry of Education and Research

Austrian Science Fund FWF

Universität Salzburg

Publisher

Informa UK Limited

Subject

Cancer Research,Molecular Biology

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