Genetic architecture of epigenetic cortical clock age in brain tissue from older individuals: alterations in CD46 and other loci

Author:

Grodstein Francine12,Lemos Bernardo3,Yang Jingyun14,de Paiva Lopes Katia14,Vialle Ricardo A.14,Seyfried Nicholas5,Wang Yanling14,Shireby Gemma6,Hannon Eilis6,Thomas Alan7,Brookes Keeley8,Mill Jonathan6,De Jager Philip L.9,Bennett David A.14

Affiliation:

1. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA

2. Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA

3. Coit Center for Longevity and Neurotherapeutics, Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA

4. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

5. Department of Biochemistry, and Center for Neurodegenerative Diseases, Emory University, Atlanta, GA, USA

6. Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK

7. Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK

8. Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK

9. Center for Translational and Computational Neuroimmunology, Department of Neurology, and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA

Funder

Alzheimer’s Society

Alzheimer’s Research UK

Medical Research Council

National Institute on Aging

Publisher

Informa UK Limited

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