Affiliation:
1. School of Mathematics, University of Leeds, Leeds LS2 9JT, UK
Abstract
Angiogenesis, the formation of new blood vessels, has become a broad subject and is a very active area for current research. This paper describes the main biological events involved in angiogenesis and their importance in cancer progression. In the first section, a fundamental overview of tumour biology is presented. In the second section, the biology of healthy blood vessels is described and, in the third section, the mechanisms of cell migration and proliferation, which are crucial to angiogenesis, are discussed. In the fourth section, a detailed account of tumour-induced angiogenesis is given, whilst the pro- and anti-angiogenic factors involved are reviewed in the fifth section. Finally, the processes of tumour invasion and metastasis are examined in the sixth section.
Subject
General Biochemistry, Genetics and Molecular Biology
Reference110 articles.
1. Acker, T. and Beck, H. and Plate, K.H. (2001) Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularisation Mech. Dev., 108, pp. 45 - 57.
2. Adatia, R. and Poggi, L. and Thompson, E.W. and Gallo, R.C. and Fassina, G.F. and Albini, A.(1992) Assessment of angiogenic potential—the use of AIDS-KS cell supernatants as an in vitro model. In Angiogenesis: Key Principles—Science–Technology–Medicine. ( pp. 321 - 326 ). Basel : Birkhauser Verlag.
3. Vajkoczy, P. and Farhadi, M. and Gaumann, A. and Heidenreich, R. and Erber, R. and Wunder, A. and Tonn, J.C. and Menger, M.D. and Breier, G. (2002) Microtumour growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2 and angiopoietin-2 J. Clin. Investig., 109, pp. 777 - 785.
4. Vernon, R.B. and Sage, E.H. (1999) A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices Microvasc. Res., 57, pp. 118 - 133.
5. Vihinen, P. and Kahari, V. (2002) Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets Int. J. Cancer, 99, pp. 157 - 166.
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