Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile-Reference-Cited by-同舟云学术

Exploring the therapeutic potential of a novel series of imidazothiadiazoles targeting focal adhesion kinase (FAK) for pancreatic cancer treatment: synthesis, mechanistic insights and promising antitumor and safety profile

Published:2024-08-02 Issue: Volume: Page:1-17
ISSN:1061-186X
Container-title:Journal of Drug Targeting
language:en
Short-container-title:Journal of Drug Targeting

Author:

Pecoraro Camilla¹,Carbone Daniela¹,Scianò Fabio²³,Terrana Francesca¹²,Xu Geng²,Bergonzini Cecilia²⁴,Roeten Margot S. F.⁵,Cascioferro Stella¹,Cirrincione Girolamo¹,Diana Patrizia¹,Giovannetti Elisa²⁶,Parrino Barbara¹

Affiliation:

1. Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Palermo, Italy

2. Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University, Amsterdam, The Netherlands

3. Lumobiotics, Karlsruhe, Germany

4. Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands

5. Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center (VUmc), Amsterdam, The Netherlands

6. Cancer Pharmacology Laboratory, Fondazione Pisana per la Scienza, Pisa, Italy

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/1061186X.2024.2385557

Reference52 articles.

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4. Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance

5. Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies