A Novel Treatment Strategy for Advanced Lacrimal Sac Carcinomas Confirmed by p16 Immunostaining-Reference-Cited by-同舟云学术

A Novel Treatment Strategy for Advanced Lacrimal Sac Carcinomas Confirmed by p16 Immunostaining

Published:2021-11-07 Issue: Volume: Page:1-6
ISSN:0882-0538
Container-title:Seminars in Ophthalmology
language:en
Short-container-title:Seminars in Ophthalmology

Author:

Ogawa Tetsuya¹,Yo Kinga¹,Okamoto Hiroki¹,Inukai Daisuke¹,Yamanaka Syunpei¹,Sano Rui¹,Fujimoto Yasushi¹,Ito Makoto²,Oshima Yukihiko²,Tsuzuki Toyonori³,Ueda Ryuzo⁴,Takahashi Yasuhiro⁵,Kakizaki Hirohiko⁵

Affiliation:

1. Department of Otorhinolaryngology, Aichi Medical University, Nagakute, Japan

2. Department of Radiology, Aichi Medical University, Nagakute, Japan

3. Department of Surgical Pathology, Aichi Medical University, Nagakute, Japan

4. Department of Tumor Immunology, Aichi Medical University, Nagakute, Japan

5. Department of Oculoplastic, Orbital & Lacrimal Surgery, Aichi Medical University, Nagakute, Japan

Publisher

Informa UK Limited

Subject

Ophthalmology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/08820538.2021.1963458

Reference21 articles.

1. Squamous Cell Carcinoma of the Lacrimal Drainage System: Case Report and Literature Review

2. Management of lacrimal sac tumours

3. En Bloc Resection of Lacrimal Sac Tumors and Simultaneous Orbital Reconstruction

4. Authors: Janakiram Trichy Narayanan, Sagar Shalini, Sharma Shilpee Bhatia, Subramaniam Vijayalakshmi Klinicka onkologie Journal. 2016; 29(4): 291-294. DOI: 10.14735/amko2016291. Background: Lacrimal sac tumors are very rare and are often missed because patients present with features consistent with chronic dacryocystitis. Squamous cell carcinoma is the commonest lacrimal sac malignancy. Although primary mucoepidermoid carcinomas of the lacrimal sac are rare, they are locally aggressive. Furthermore, their proximity to vital structures and the skull base makes them potentially life-threatening. Multidisciplinary management is required, and wide excision followed by chemoradiation is the recommended treatment. Case: Here, we report a 65-year-old male who presented with watering eyes and a mass in the region of the medial canthus. A dia gnosis of primary mucoepidermoid carcinoma of the lacrimal sac was made, and the case was managed successfully with radical surgery and reconstruction. The tumor was resected using the extended Lynch-Howarth incision and the resulting defect was reconstructed using a forehead fl ap. Histopathological examination of the excised specimen revealed mucoepidermoid carcinoma. Immunohistochemical analysis revealed that the specimen was positive for epithelial growth factor receptor and Ki-67 protein. The patient was referred for post-operative chemoradiation. The literature is reviewed and pathological features, including immunohistochemistry are discussed. Conclusion: Primary mucoepidermoid carcinoma of the lacrimal sac is a rare, locally aggressive tumor that is often mistaken for dacryocystitis. The treatment of choice is radical surgery followed by chemoradiation. http://dx.doi.org/10.14735/amko2016291 Information for Professionals News Archive Press Releases Klinicka onkologie Journal Archive Search for articles Information for Contributors Author Index About the Journal Calendar of Events About Linkos: “What is missing in English version”

5. Human papillomavirus: cause of epithelial lacrimal sac neoplasia?

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1. Lacrimal sac squamous cell carcinoma: From resection to prosthetic rehabilitation. A case report;Clinical Case Reports;2023-09

2. Three Cases of Squamous Cell Carcinoma of the Lacrimal Drainage System;Practica Oto-Rhino-Laryngologica;2023