Synthesis and control of process-related impurities in the β-lactamase inhibitor drug substance zidebactam

Author:

Pund Amit A.1ORCID,Rane Vipul P.1,Raut Vivek T.1,Ahirrao Vinod K.1,Yeole Ravindra D.1,Joshi Sanjeev1,Bhavsar Satish1,Rafeeq Mohammad1,Yadav Ramprasad1,Merwade Arvind Y.1ORCID

Affiliation:

1. Wockhardt Research Centre, D-4, MIDC, Chikalthana, Aurangabad, India

Publisher

Informa UK Limited

Subject

Organic Chemistry

Reference10 articles.

1. Joshi, S.; Wankhede, K.; Jadhav, S.; Pawar, S.; Ahirrao, V.; Bhawsar, S.; Deshpande, P.; Yeole, R.; Patel, M. A. Process for Preparation of (2S,5R)-7-Oxo-6-Sulphooxy-2-[N'-((3R)-Piperidin-3-Carbonyl)Hydrazinocarbonyl]-1,6-Diaza-Bicyclo[3.2.1]Octane. U.S. Patent 9657021B2 (717/MUM/2013), WO2014/135931, September 12, 2014.

2. Patel, M.; Deshpande, P.; Bhawsar, S.; Bhagwat, S.; Jafri, M.; Mishra, A.; Pavase, L.; Gupta, S.; Kale, R.; Joshi, S. 1,6-Diaza-Bicyclo[3.2.1]Octane-7-One Derivatives and Their Use in Treatment of Bacterial Infections. U.S. Patent 20140148431A1, May 29, 2014.

3. Patel, M.; Deshpande, P.; Bhawsar, S.; Bhagwat, S.; Jafri, M.; Mishra, A.; Pavase, L.; Gupta, S.; Kale, R.; Joshi, S. 1,6-Diazabicyclo[3,2,1]Octan-7-One Derivatives and Their Use in the Treatment of Bacterial Infections. U.S, 8822450B2, September 02, 2014.

4. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234

5. Potent β-Lactam Enhancer Activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates

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