A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib
Author:
Affiliation:
1. Key Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University , Shenyang , P. R. China
Funder
Liaoning Provincial Natural Science Foundation of China
Publisher
Informa UK Limited
Subject
Organic Chemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/00397911.2018.1564832
Reference22 articles.
1. A Phase I Dose–Escalation Study of Regorafenib (BAY 73–4506), an Inhibitor of Oncogenic, Angiogenic, and Stromal Kinases, in Patients with Advanced Solid Tumors
2. Stiehl, J. ; Heilmann, W. ; Loegers, M. ; Rehse, J. ; Gottfried, M. ; Wichmann, S . Process for the Preparation of 4-{4-[({[4-Chloro-3-(Trifluoromethyl)-Phenyl]Amino}Carbonyl)Amino]-3-Fluorophenoxy}-N-Methylpyridine-2-Carboxamide, Its Salts and Monohydrate. WO Patent 2011128261A1, Oct 20, 2011.
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