Effect of Clofibric Acid on Desmin and Vimentin Contents in Rat Myocardiocytes-Reference-Cited by-同舟云学术

Effect of Clofibric Acid on Desmin and Vimentin Contents in Rat Myocardiocytes

Published:2006-09 Issue:5 Volume:25 Page:403-408
ISSN:1091-5818
Container-title:International Journal of Toxicology
language:en
Short-container-title:Int J Toxicol

Author:

Sampayo-Reyes Adriana¹,Narro-Juárez Antonio¹,Saíd-Fernández Salvador²,Lozano-Garza Héctor G.²,Vargas-Villarreal Javier²,Mata-Cárdenas Benito D.²,Morales-Aguilera Antonio³,González-Garza María Teresa³,Cortés-Gutiérrez Elva I.⁴,Cerda-Flores Ricardo M.⁴,Martínez-Rodríguez Herminia G.⁵

Affiliation:

1. División de Farmacología y Toxicología del Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México

2. División de Biología Celular y Molecular del Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México

3. Escuela de Medicina del Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Nuevo León, México

4. División de Genética del Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México

5. Unidad de Laboratorios de Ingeniería y Expresión Genética, Departamento de Bioquímica de la Facultad de Medicina de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México

Abstract

The aim of this experimental study was to analyze in vitro effects of clofibric acid on vimentin and desmin contents in rat myocardiocytes, which was carried out in primary myocardiocyte cells that were treated only with clofibric acid at 0.1 mM. The measurement of vimentin and desmin were done by Western blotting and densitometry. This study showed that myocardiocytes exposed to clofibric acid exhibit a 26.3% decrease in vimentin and a 42.1% decrease in desmin. Considering the role that these intermediate filaments play in the anchorage and cellular organization of myocardiocytes, the decrease of desmin and vimentin observed in cells treated with clofibric acid may be partially responsible for the adverse effects observed in patients. In conclusion, the alteration of cytoskeletal proteins may be a cause of cardiopathy in patients treated with these compounds.

Publisher

SAGE Publications

Subject

Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1080/10915810600846989

Reference21 articles.

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