Mechanism and Treatment of Sulfide-Induced Coma: A Rat Model-Reference-Cited by-同舟云学术

Mechanism and Treatment of Sulfide-Induced Coma: A Rat Model

Published:2008-05 Issue:3 Volume:27 Page:287-293
ISSN:1091-5818
Container-title:International Journal of Toxicology
language:en
Short-container-title:Int J Toxicol

Author:

Almeida A. F.¹,Nation P. N.²,Guidotti T. L.³

Affiliation:

1. Department of Public Health Sciences, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada TG6 2G3

2. Health Sciences Laboratory Animal Services, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

3. Department of Environmental and Occupational Health, School of Public Health & Health Services, The George Washington University, Washington DC 20052

Abstract

Sodium hydrosulfide and dimethylsulfide duplicate the effects of hydrogen sulfide in causing coma in Sprague-Dawley rats and are additive for lethality. Nitrite, pyruvate and dithiothreitol had no significant effect on coma or lethality but bicarbonate with and without glucose reduced duration of coma. This finding suggests an antidotal treatment.

Publisher

SAGE Publications

Subject

Toxicology

Link

http://journals.sagepub.com/doi/pdf/10.1080/10915810802210166

Reference36 articles.

1. The possible role of hydrogen sulfide as an endogenous neuromodulator

2. Differential sensitivity of lung and brain to sulfide exposure: a peripheral mechanism for apnea

3. A Critical Review of the Literature on Hydrogen Sulfide Toxicity

4. Nitrite as an antidote for acute hydrogen sulfide intoxication?

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