Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)-Reference-Cited by-同舟云学术

Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)

Published:2020-08-23 Issue:9-10 Volume:32 Page:369-371
ISSN:0895-8378
Container-title:Inhalation Toxicology
language:en
Short-container-title:Inhalation Toxicology

Author:

Clewell H. J.¹,Campbell J. L.¹,Van Landingham C.²,Franzen A.²,Yoon M.³,Dodd D. E.⁴,Andersen M. E.⁴,Gentry P. R.³

Affiliation:

1. Research Triangle Park, Ramboll US Corporation, Charlotte, North Carolina, USA

2. Ramboll US Corporation, Monroe, Louisiana, USA

3. ToxStrategies, Inc., Cary, North Carolina, USA

4. Research Triangle Park, The Hamner Institutes for Health Sciences, North Carolina, USA

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

https://www.tandfonline.com/doi/pdf/10.1080/08958378.2020.1817199

Reference9 articles.

1. A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: Application to β-chloroprene

2. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride

3. Chloroprene (2-chloro-1, 3-butadiene) — What is the Evidence for Its Carcinogenicity?

4. Kinetic Modeling of β-Chloroprene Metabolism: I. In vitro Rates in Liver and Lung Tissue Fractions from Mice, Rats, Hamsters, and Humans

5. Kinetic Modeling of β-Chloroprene Metabolism: II. The Application of Physiologically Based Modeling for Cancer Dose Response Analysis Portions of this research were conducted at the National Health and Environmental Effects Laboratory (NHEERL). The research in this article has been reviewed by NHEERL and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the agency, nor does mention of a trade name or commercial products constitute endorsement or recommendation for use.2Data for 2002 from International Institute of Synthetic Rubber Producers, Houston, TX.

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1. Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene;Frontiers in Pharmacology;2023-08-17