1. a Faculty of Pharmacy , Pharmacognosy Department, Assiut University , Assiut 71526, Egypt
2. b Faulty of Pharmacy , Pharmacognosy Department, Al-Azhar University , Assiut, Egypt
3. c Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University , Universitätsstraße 1, 40225 Düsseldorf, Germany