Genetic algorithm-de novo, molecular dynamics and MMGBSA based modelling of a novel Benz-pyrazole based anticancer ligand to functionally revert mutant P53 into wild type P53
Author:
Affiliation:
1. Dr. B.C. Roy College of Pharmacy & Allied Health Sciences, Durgapur, India
2. Department of Chemical Technology, University of Calcutta, Kolkata, India
3. Orange Business, Vishwaroop IT Park, Navi Mumbai, India
Publisher
Informa UK Limited
Subject
Condensed Matter Physics,General Materials Science,General Chemical Engineering,Modeling and Simulation,Information Systems,General Chemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/08927022.2023.2185079
Reference47 articles.
1. A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C
2. Effect of Y220C Mutation on p53 and Its Rescue Mechanism: A Computer Chemistry Approach
3. Role of p53 in Cell Death and Human Cancers
4. Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
5. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines
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