The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors
Author:
Affiliation:
1. Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA
2. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA
Funder
National Institutes of Health
Publisher
Informa UK Limited
Subject
Cell Biology,Developmental Biology,Molecular Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/15384101.2018.1475827
Reference42 articles.
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2. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
3. Ashwell S. Checkpoint kinase and Wee1 inhibitors as anticancer therapeutics. DNA Repair in Cancer Therapy 2012; Chapter 10:211–234.
4. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
5. Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination
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