Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells

Author:

Fan Dandan1,Yue Qi2,Chen Jian1,Wang Cong1,Yu Ruilin3,Jin Ziyi1,Yin Shujie1,Wang Qinyue4,Chen Luo1,Liao Xueling1,Peng Chengyuan5,Zhang Jianpin6,Cao Zhonglian1,Mao Ying2,Huang Ruimin57ORCID,Chen Liang28,Li Cong1ORCID

Affiliation:

1. Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, China

2. Department of Neurosurgery, Huashan Hospital and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China

3. Department of Chemistry, Purdue University, West Lafayette, Indiana, USA

4. Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China

5. Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

6. Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China

7. School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China

8. Tianqiao and Chrissy Chen Institute for Translational Research, Shanghai, China

Funder

The Program of Shanghai Science and Technology Committee

Shanghai Municipal Science and Technology Major Project

National Natural Science Foundation of China

National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program”, China

the Fudan-SIMM Joint Research Fund

National Key R&D Programs of China

National Science Foundation for Distinguished Young Scholars of China

One Hundred Talent Program of Chinese Academy of Sciences

Shanghai Hospital Development Center

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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