A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model

Author:

Ramos da Silva Jamile1,Ramos Moreno Ana Carolina1,Silva Sales Natiely1,de Oliveira Silva Mariângela1,Aps Luana R. M. M.1,Porchia Bruna F.M.M.12,Bitencourt Rodrigues Karine1,Cestari Moreno Natália34,Venceslau-Carvalho Aléxia Adrianne1,Menck Carlos Frederico M.3,de Oliveira Diniz Mariana15,de Souza Ferreira Luís Carlos1

Affiliation:

1. Vaccine Development Laboratory, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

2. Laboratory of Tumor Immunology, Department of Immunology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

3. DNA Repair Laboratory, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

4. Mitochondrial Genetics Lab. Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil

5. Division of Infection and Immunity, University College London, 5 University St, Bloomsbury, London, UK

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

CAPES

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

Reference46 articles.

1. Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

2. Cancer statistics, 2020

3. WHO report on cancer: setting priorities, investing wisely and providing care for all. WHO-CancerReport-2020-Global Profile. Geneva:World Health Organization; 2020.

4. Survival rates for cervical cancer. American Cancer Society. 2020. Web page (https://www.cancer.org/cancer/cervical-cancer/detection-diagnosis-staging/survival/en/, accessed January 2021).

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