<i>CEBPA</i> mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition-Reference-Cited by-同舟云学术

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CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition

Published:2022-01-05 Issue:1 Volume:11 Page:
ISSN:2162-402X
Container-title:OncoImmunology
language:en
Short-container-title:OncoImmunology

Author:

Liu Meng¹,Du Mengbao¹,Yu Jian¹,Qian Zijun²,Gao Yang²,Pan Wenjue²,Zhao Xiujie²,Wang Mowang¹,Li Huimin³,Zheng Jiaqi³,Huang Qianshuo³,Wang Li-Mengmeng¹⁴⁵,Xiao Haowen²⁴⁵

Affiliation:

1. Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P R China

2. Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P R China

3. Undergraduate School, Zhejiang University School of Medicine, Hangzhou, P R China

4. Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P R China

5. Institute of Hematology, Zhejiang University, Hangzhou, P R China

Funder

National Natural Science Foundation of China

Zhejiang Province Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2021.2016158

Reference36 articles.

1. Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation

2. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

3. Somatic CEBPA Mutations Are a Frequent Second Event in Families With Germline CEBPA Mutations and Familial Acute Myeloid Leukemia

4. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

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1. Epigenetic regulation of NKG2D ligand and the rise of NK cell-based immunotherapy for cancer treatment;Frontiers in Oncology;2024-08-05

2. Targeting LSD1 in cancer: Molecular elucidation and recent advances;Cancer Letters;2024-08

3. C/EBPα-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription;Journal of Experimental & Clinical Cancer Research;2024-03-13

4. Risk factors and survival analysis of human leukocyte antigen loss in relapsed acute myeloid leukaemia/myelodysplastic syndrome patients after allogeneic haematopoietic stem cell transplantation;British Journal of Haematology;2024-02-07

5. BTK inhibitors upregulate NKG2D ligand expression by modulating IL-10/STAT3 in activated non-GCB diffuse large B-cell lymphoma cells;2023-12-13

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