Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6-Reference-Cited by-同舟云学术

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6

Published:2020-01-01 Issue:1 Volume:9 Page:
ISSN:2162-402X
Container-title:OncoImmunology
language:en
Short-container-title:OncoImmunology

Author:

Czerwinska Patrycja¹²^ORCID,Rucinski Marcin³,Wlodarczyk Nikola⁴,Jaworska Anna¹,Grzadzielewska Iga¹,Gryska Katarzyna¹,Galus Lukasz⁵⁶,Mackiewicz Jacek²⁵,Mackiewicz Andrzej¹²^ORCID

Affiliation:

1. Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland

2. Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland

3. Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland

4. Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Poznan, Poland

5. Department of Medical and Experimental Oncology, Heliodor Swiecicki University Hospital, Poznan University of Medical Sciences, Poznan, Poland

6. Department of Chemotherapy, Greater Poland Cancer Centre, Poznan, Poland

Funder

National Center for Research and Development

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2019.1710063

Reference52 articles.

1. Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection

2. Therapeutic gene modified cell based cancer vaccines

3. Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma

4. Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients

5. Re-induction using whole cell melanoma vaccine genetically modified to melanoma stem cells-like beyond recurrence extends long term survival of high risk resected patients - updated results

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