A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer

Author:

Avanzino Brian C.12,Prabhakar Kirthana12,Dalvi Pranjali12ORCID,Hartstein Sharon13,Kehm Hannes1,Balasubramani Aarti13,Boudreau Andrew A.1ORCID,Buelow Ben1,Chang Karen1,Davison Laura M.1,Iyer Suhasini1,Kalwit Vidyut12,Lewis Wilson Kristin4,Malik-Chaudhry Harbani K.13ORCID,Pierson Will56,Pineda Geovanni57,Rangaswamy Udaya S.12ORCID,Saiganesh Sowmya12,Schellenberger Ute1ORCID,Ugamraj Harshad S.18,Yabut Rodolfovan D.4,Buelow Roland1,Chapman Jocelyn57,Trinklein Nathan D.1,Harris Katherine E.12ORCID

Affiliation:

1. Teneobio, Inc, Newark, CA, United States

2. Oncology Research, Amgen Inc., Newark, CA, USA

3. Therapeutic Discovery, Amgen Inc., Newark, CA, USA

4. Translational Safety & Bioanalytical Sciences, Amgen Inc., South San Francisco, CA, USA

5. Division of Gynecologic Oncology, University of California, San Francisco, CA, USA

6. University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

7. Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA

8. Process Development, Amgen Inc., Newark, CA, USA

Funder

Teneobio and in part by NIH SBIR

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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