Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade

Author:

Nazerai Loulieta12,Willis Shona Caroline12,Yankilevich Patricio3,Di Leo Luca1,Bosisio Francesca Maria4,Frias Alex1,Bertolotto Corine56,Nersting Jacob2,Thastrup Maria2,Buus Soren7,Thomsen Allan Randrup7,Nielsen Morten8,Rohrberg Kristoffer Staal9,Schmiegelow Kjeld2,De Zio Daniela110ORCID

Affiliation:

1. Melanoma Research Team, Danish Cancer Society Research Center, Copenhagen, Denmark

2. Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

3. Bioinformatics Core Facility, Instituto de Investigación En Biomedicina de Buenos Aires (Ibioba), Buenos Aires, Argentina

4. Lab of Translational Cell and Tissue Research, University of Leuven, Leuven, Belgium

5. Universite Côte d’Azur, Nice, France

6. INSERM, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020, Centre Méditerranéen de Médecine Moléculaire, Nice, France

7. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

8. Department of Health Technology, Section for Bioinformatics, Technical University of Denmark, Lyngby, Denmark

9. Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

10. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

Funder

Børnecancerfonden

Danmarks Grundforskningsfond

LEO Fondet

Melanoma Research Alliance young investigator

Sundhedsstyrelsen

the Danish Cancer Society

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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