Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5-Reference-Cited by-同舟云学术

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Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5

Published:2018-11-02 Issue:2 Volume:8 Page:e1534664
ISSN:2162-402X
Container-title:OncoImmunology
language:en
Short-container-title:OncoImmunology

Author:

Carlsten Mattias¹^ORCID,Namazi Ali¹,Reger Robert¹,Levy Emily¹,Berg Maria¹,St. Hilaire Cynthia²^ORCID,Childs Richard W.¹

Affiliation:

1. Laboratory of Transplantation Immunotherapy, Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA

2. Laboratory of Cardiovascular Regenerative Medicine, Center for Molecular Medicine, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD USA

Funder

Dean O’Neill/Bill Rancic Fellowship

HHS | NIH | National Heart, Lung, and Blood Institute

Swedish Research Council

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2018.1534664

Reference50 articles.

1. Functions of natural killer cells

2. Human NK Cell Education by Inhibitory Receptors for MHC Class I

3. NK cell education: not an on-off switch but a tunable rheostat

4. Proteasome inhibitors in the treatment of multiple myeloma

5. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

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1. Endoplasmic reticulum stress in diseases;MedComm;2024-08-26

2. TRAIL-induced apoptosis and proteasomal activity – Mechanisms, signalling and interplay;Biochimica et Biophysica Acta (BBA) - Molecular Cell Research;2024-04

3. HLA class I NK-epitopes and KIR diversities in patients with multiple myeloma;Immunogenetics;2024-03-13

4. Natural killer cells affect the natural course, drug resistance, and prognosis of multiple myeloma;Frontiers in Cell and Developmental Biology;2024-02-12

5. Strategies to disrupt NKG2A:HLA-E interactions for improved anti-cancer immunity;Oncotarget;2024-01-06

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