DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma

Author:

Xu-Monette Zijun Y.1ORCID,Luo Cancan1,Yu Li1,Li Yong2ORCID,Bhagat Govind3ORCID,Tzankov Alexandar4ORCID,Visco Carlo5,Fan Xiangshan1,Dybkaer Karen6ORCID,Sakhdari Ali7ORCID,Wang Nicholas T.1,Yuan Alyssa F.1,Chiu April8,Tam Wayne9ORCID,Zu Youli10ORCID,Hsi Eric D.11ORCID,Perry Anamarija M.12,Song Wenting1,O’Malley Dennis13,Au Qingyan13,Nunns Harry13,Go Heounjeong14ORCID,Møller Michael B.15ORCID,Parsons Benjamin M.16ORCID,Montes-Moreno Santiago17ORCID,Ponzoni Maurilio18,Ferreri Andrés J.M.18,Sohani Aliyah R.19,Abramson Jeremy S.19,Xu Bing1,Young Ken H.120ORCID

Affiliation:

1. Hematopathology Division and Department of Pathology, Duke University Medical Center, Durham, NC, USA

2. Department of Medicine, Baylor College of Medicine, Houston, TX, USA

3. Department of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, NY, USA

4. Institute of Pathology, University Hospital Basel, Basel, Switzerland

5. Department of Engineering for Innovation Medicine, Section of Hematology, University of Verona, Verona, Italy

6. Clinical Department, Aalborg University Hospital, Aalborg, Denmark

7. Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada

8. Hematopathology Department, Mayo Clinic, Rochester, MN, USA

9. Department of Pathology, Northwell Health, New York, NY, USA

10. Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, TX, USA

11. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

12. Department of Pathology, University of Michigan, Ann Arbor, MI, USA

13. NeoGenomics Laboratories, Aliso Viejo, CA, USA

14. Department of Pathology, Asan Medical Center, Ulsan University College of Medicine, Seoul, South Korea

15. Department of Pathology, Odense University Hospital, Odense, Denmark

16. Hematology & Oncology, Gundersen Lutheran Health System, La Crosse, WI, USA

17. Translational Hematopathology Laboratory and Anatomic Pathology Service, Valdecilla/IDIVAL, UNICAN, Santander, Spain

18. Pathology Unit, Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy

19. Massachusetts General Hospital, Center for Lymphoma, Harvard Medical School, Boston, MA, USA

20. Duke Cancer Institute, Durham, NC, USA

Funder

KHY was also supported by The Duke University Institutional Research Grant Award and the Hagemeister Lymphoma Foundation

Publisher

Informa UK Limited

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