Redox high phenotype mediated by KEAP1/STK11/SMARCA4/NRF2 mutations diminishes tissue-resident memory CD8+ T cells and attenuates the efficacy of immunotherapy in lung adenocarcinoma

Author:

Wei Xue-Wu12,Lu Chang2,Zhang Yi-Chen2,Fan Xue2,Xu Chong-Rui2,Chen Zhi-Hong3,Wang Fen4,Yang Xiao-Rong2,Deng Jia-Yi2,Yang Ming-Yi2,Gou Qing5,Mei Shi-Qi2,Luo Wei-Chi2,Zhong Ri-Wei2,Zhong Wen-Zhao2,Yang Jin-Ji2,Zhang Xu-Chao2,Tu Hai-Yan2,Wu Yi-Long2,Zhou Qing12ORCID

Affiliation:

1. School of Medicine, South China University of Technology, Guangzhou, China

2. Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

3. Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Lung Cancer Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

4. Department of Oncology, Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Cancer Institute, Peking University Shenzhen Hospital, Shenzhen-Peking University-Hong Kong University of Science and Technology Medical Center, Shenzhen, China

5. Department of Interventional Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China

Funder

National Natural Science Foundation of China

Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer

Publisher

Informa UK Limited

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